Are your patients having a hard time paying for their MEDS?

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Semaglutide: 

Sold under the brand names Ozempic (FDA Approved 2017), Wegovy (FDA Approved 2021), & Rybelsus (FDA Approved 2019).

Tirzepatide: 

Sold under the brand name Mounjaro (FDA Approved 2022).

Approved by the FDA, both are anti-diabetic medications used for the  treatment of type 2 diabetes & as anti-obesity medications for long-term weight management & with all weight-loss strategies, it does require sustained lifestyle changes in order to continue your  success. 

These are perfect weight loss medications for people who are  overweight and obese, with or without diabetes. These medications will simply help you lose weight on the scale along with significant fat loss  reduction. 

Semaglutide is a medication that has been used to treat diabetes since 2019. It works by mimicking the hormone glucagon-like peptide-1 receptor agonist  (GLP-1), which helps the body regulate blood sugar levels. It also  reduces hunger, regulates appetite, & increases feelings of satiety, making it easier to reduce calorie intake. In addition, Semaglutide has been shown to reduce cholesterol levels, triglycerides, as well as overall mortality rates in people with type 2 diabetes. This medication will simply help you lose weight on the scale & is indicated for the treatment of overweight & obesity.

What else does it do:

Brain

• Increases synaptic transmission, nerve protection, memory, neuronal stem cell proliferation, motor function, & satiety
• Decreases neuroinflammation

CVD (cardiovascular disease)

• Increases CVD protection, heart rate, anti-inflammatory actions
• Improves endothelial function, myocardial ischemia, lipids

Liver

• Decreased glucose production, liver fat content, liver enzymes, & hepatic steatosis

Pancreas

• Increases insulin secretion
• Increases & protects pancreatic β cells

Gut

• Decreased gastric emptying & peristalsis, thus increasing  nutrient absorption & normalizes PPG (postprandial glucose) elevations.

Note: It is important to have a healthy gut for optimal nutrient absorption & hormone balance

Tirzepatide is a medication that was recently approved for use in adults with type 2  diabetes. It is a dual glucose-dependent insulinotropic polypeptide  (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA). This  means it works by imitating not one, but two unique incretin hormones  produced by the human body. It works by stimulating GLP-1 production in  the body, which helps the body produce more insulin when needed. GIP has been shown to decrease food intake & increase energy expenditure  therefore resulting in weight reductions & when combined with GLP-1  receptor agonism, may result in greater effects on markers of metabolic  dysregulation such as body weight, glucose, & lipides. Additionally,  Tirzepatide has been found to lower fasting blood glucose levels &  increase weight loss in participants who were overweight or obese at the start of clinical trials. This suggests that it may be beneficial for  those looking to shed excess pounds quickly & safely. This  medication has all the benefits of Semaglutide for weight loss with  appetite suppression but it also adds the component of fat loss with it,  in other words, you’ll lose weight & keep it off for the long haul.

What else does it do:

• Stimulate pancreatic β cells insulin release.
• Note: in DM (diabetes mellitus) patients GIP secretion is reduced, however, can be restored by improving glycemic control.
• GIP: Protects against hypoglycemia; improves TG  (triglyceride) clearance; improves adipose insulin sensitivity, which  may prevent ectopic fat deposition.

Who should not or those to be cautious taking these medications:

• Shouldn’t: Those with personal or family history of  thyroid cancer; multiple endocrine neoplasia syndrome type 2; other DM  medications, especially insulin & sulfonylureas; history of  pancreatitis, history of gall bladder disease; kidney disease; tachycardia; retinopathy; pregnant, breast-feeding, or trying to get pregnant.
• Caution: Metformin; those with an elevated HR, as  there are GLP-1 receptors in the SA Node (sinoatrial node); GI disorders; those with HTN (high blood pressure-hypertension) on BP (blood pressure) medications.
  • Decreased glucose production, liver fat content, liver enzymes, & hepatic steatosis.

Additional Benefits:

• Reduced inflammation: Both medications are proven  to reduce inflammation markers which leads to decreased inflammation  response & oxidative stress.
• Regulates digestions: This regulation is directly tied to how  quickly food moves from the stomach to the intestines. Overall, this will leave you feeling fuller longer & help control the sugar absorption in the intestines.
• Improved metabolic function: These medications  regulate blood sugar levels by increasing insulin & decreasing  glucagon-only when the blood sugar levels are high. It also improves the  whole-body energy metabolism by increasing insulin sensitivity of muscle cells & regulating fat cell development. Even if you are not severely overweight, you can’t go wrong with improving your metabolic profile!
• BPC-157: This peptide is added to both medications & acts systematically in the digestive tract to combat leaky gut, IBS, gastro intestinal cramps, helps maintain integrity of mucosal lining GI tract,  helps improve digestive function, as well as improves gut related  issues, & helps reduce side effects of the medications.
• Other: May reduce the likelihood of cardiovascular  events such as heart attack or stroke, or death in adults with type 2  diabetes and known heart disease. Helps release insulin and lowers the  amount of glucose produced by the liver when glucose rises at mealtime.  Also slows the absorption of mealtime glucose.